Stabilizing selection and metabolism
نویسندگان
چکیده
منابع مشابه
Stabilizing selection in Drosophila melanogaster.
Stabilizing selection operates on egg length in Drosophila melanogaster. The percentage of eggs hatching decreases with departure from the population mean size; this effect cannot be explained by the model of neutral variation in a quantitative character. The finding of stabilizing selection agrees with expectations for a character inherited primarily through additive effects.
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Genomic traits such as codon usage and the lengths of noncoding sequences may be subject to stabilizing selection rather than purifying selection. Mutations affecting these traits are often biased in one direction. To investigate the potential role of stabilizing selection on genomic traits, the effects of mutational bias on the equilibrium value of a trait under stabilizing selection in a fini...
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Molecular phenotypes are important links between genomic information and organismic functions, fitness, and evolution. Complex phenotypes, which are also called quantitative traits, often depend on multiple genomic loci. Their evolution builds on genome evolution in a complicated way, which involves selection, genetic drift, mutations and recombination. Here we develop a coarse-grained evolutio...
متن کاملOn a genetic model of intraspecific competition and stabilizing selection.
A genetic model is investigated in which two recombining loci determine the genotypic value of a quantitative trait additively. Two opposing evolutionary forces are assumed to act: stabilizing selection on the trait, which favors genotypes with an intermediate phenotype, and intraspecific competition mediated by that trait, which favors genotypes whose effect on the trait deviates most from tha...
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The ability to engineer novel protein folds, conformations, and enzymatic activities offers enormous potential for the development of new protein therapeutics and biocatalysts. However, many de novo and redesigned proteins exhibit poor hydrophobic packing in their predicted structures, leading to instability or insolubility. The general utility of rational, structure-based design would greatly ...
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ژورنال
عنوان ژورنال: Heredity
سال: 1988
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.1988.135